Special Issue : Pharmacology of purinergic receptors – Honorary Special Issue Dedicated to Prof. Pier Andrea Borea
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Journal: Biomolecules
Special Issue Title: Pharmacology of purinergic receptors – Honorary Special Issue Dedicated to Prof. Pier Andrea Borea
Submission Deadline: March 15, 2023
Special Issue Introduction: Dear Colleagues, Biomolecules invites submissions for a Special Issue in honor of Professor Pier Andrea Borea in recognition for his remarkable pharmacological contribution in the field of purinergic receptors. Professor Pier Andrea Borea devoted most of his scientific research to the study of adenosine receptors starting from the early 1990s, when the significance of the purinergic system in the control of numerous human body processes was just beginning to be recognized. Since then, intense scientific work has been conducted to demonstrate the role of purines as important extracellular messengers, through their interaction with GPCR and channel receptors, both markers and drug-target for the diagnosis and treatment of a wide range of diseases. It is clear today that the search for molecules that can alter the activity of purinergic receptors might lead to the development of novel medications for illnesses of the central and peripheral nervous systems, as well as the immune system, spanning from inflammatory disorders, ischemia, epilepsy, neuropathic pain, cancer. These years of research have resulted in the development of a large number of ligands designed to interact with purinergic receptors, some of which have found utility in both diagnostic and therapeutic applications. In this Special Issue of Biomolecules, we invite your contributions, either in the form of original research articles or reviews on all aspects related to recent advances in the fields of purinergic receptors in health and disease, including cardiovascular, neurological, cancer, inflammatory, and immunological disorders. This Special Issue is dedicated to Professor Pier Andrea Borea for his invaluable contribution to this field.
We look forward to receiving your contributions
Katia Varani, Stefania Gessi, Stefania Merighi, Fabrizio Vincenzi
Special Issue : Purinergic Signaling 2020: the State-of-The-Art Commented by the Members of the Italian Purine Club
Special Issue : Geoffrey Burnstock - an Accidental Pharmacologist
https://www.sciencedirect.com/journal/biochemical-pharmacology/vol/187/suppl/C
Biochemical Pharmacology, Vol. 187, May 2021
Selected articles by member groups
Affiliation: University of Milan
Principal Investigator: Maria Pia Abbracchio
[1] Lecca D, Fumagalli M, Ceruti S, Abbracchio MP. Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate. Philos Trans R Soc Lond B, 2016; 371: 20150433.
https://www.ncbi.nlm.nih.gov/pubmed/27377726
[2] Marschallinger J, Schäffner I, Klein B, Gelfert R, Rivera FJ, Illes S, Grassner L, Janssen M, Rotheneichner P, Schmuckermair C, Coras R, Boccazzi M, Chishty M, Lagler FB, Renic M, Bauer HC, Singewald N, Blümcke I, Bogdahn U, Couillard-Despres S, Lie DC, Abbracchio MP, Aigner L. Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat Commun, 2015; 6: 8466.
http://www.ncbi.nlm.nih.gov/pubmed/26506265
[3] Fumagalli M, Bonfanti E, Daniele S, Zappelli E, Lecca D, Martini C, Trincavelli ML, Abbracchio MP. The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. Glia, 2015; 63: 2327-2339.
http://www.ncbi.nlm.nih.gov/pubmed/26228571
[4] Boccazzi M, Rolando C, Abbracchio MP, Buffo A, Ceruti S. Purines regulate adult brain subventricular zone cell functions: contribution of reactive astrocytes. Glia, 2014; 62: 428-439.
http://www.ncbi.nlm.nih.gov/pubmed/24382645
[5] Ceruti S, Villa G, Fumagalli M, Colombo L, Magni G, Zanardelli M, Fabbretti E, Verderio C, van den Maagdenberg AM, Nistri A, Abbracchio MP. Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain. J Neurosci, 2011; 31: 3638-3649.
http://www.ncbi.nlm.nih.gov/pubmed/21389219
Affiliation: University of Ferrara
Principal Investigator: Elena Adinolfi
[1] De Marchi E, Orioli E, Dal Ben D, Adinolfi E. P2X7 Receptor as a Therapeutic Target. Adv Protein Chem Struct Biol, 2016; 104: 39-79.
http://www.ncbi.nlm.nih.gov/pubmed/27038372
[2] Amoroso F, Capece M, Rotondo A, Cangelosi D, Ferracin M, Franceschini A, Raffaghello L, Pistoia V, Varesio L, Adinolfi E. The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma. Oncogene, 2015; 34: 5240-5251.
http://www.ncbi.nlm.nih.gov/pubmed/25619831
[3] Adinolfi E, Capece M, Franceschini A, Falzoni S, Giuliani AL, Rotondo A, Sarti AC, Bonora M, Syberg S, Corigliano D, Pinton P, Jorgensen NR, Abelli L, Emionite L, Raffaghello L, Pistoia V, Di Virgilio F. Accelerated tumor progression in mice lacking the ATP receptor P2X7. Cancer Res, 2015; 75: 635-644.
http://www.ncbi.nlm.nih.gov/pubmed/25542861
[4] Adinolfi E, Capece M, Amoroso F, De Marchi E, Franceschini A. Emerging roles of P2X receptors in cancer. Curr Med Chem, 2015; 22: 878-890.
http://www.ncbi.nlm.nih.gov/pubmed/25312206
[5] Giuliani AL, Colognesi D, Ricco T, Roncato C, Capece M, Amoroso F, Wang QG, De Marchi E, Gartland A, Di Virgilio F, Adinolfi E. Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma. PLoS One, 2014; 9: e107224.
http://www.ncbi.nlm.nih.gov/pubmed/25226385
Affiliation: University of Pisa
Principal Investigator: Corrado Blandizzi
[1] Antonioli L, Fornai M, Awwad O, Giustarini G, Pellegrini C, Tuccori M, Caputi V, Qesari M, Castagliuolo I, Brun P, Giron MC, Scarpignato C, Blandizzi C, Colucci R. Role of the A2B receptor-adenosine deaminase complex in colonic dysmotility associated with bowel inflammation in rats. Br J Pharmacol, 2014; 171: 1314-1329.
http://www.ncbi.nlm.nih.gov/pubmed/24286264
[2] Antonioli L, Giron MC, Colucci R, Pellegrini C, Sacco D, Caputi V, Orso G, Tuccori M, Scarpignato C, Blandizzi C, Fornai M. Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats. PLoS One, 2014; 9: e116253.
http://www.ncbi.nlm.nih.gov/pubmed/25549098
[3] Antonioli L, Blandizzi C, Pacher P, Haskó G. Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer, 2013; 13: 842-857.
http://www.ncbi.nlm.nih.gov/pubmed/24226193
[4] Antonioli L, Fornai M, Colucci R, Ghisu N, Tuccori M, Awwad O, Bin A, Zoppellaro C, Castagliuolo I, Gaion RM, Giron MC, Blandizzi C. Control of enteric neuromuscular functions by purinergic A3 receptors in normal rat distal colon and experimental bowel inflammation. Br J Pharmacol, 2010; 161: 856-871.
http://www.ncbi.nlm.nih.gov/pubmed/20860664
[5] Antonioli L, Fornai M, Colucci R, Awwad O, Ghisu N, Tuccori M, Da Settimo F, La Motta C, Natale G, Duranti E, Virdis A, Blandizzi C. The blockade of adenosine deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors. J Pharmacol Exp Ther, 2010; 335: 434-442.
Affiliation: University of Ferrara
Principal Investigator: Pier Andrea Borea, Katia Varani
[1] Vincenzi F, Targa M, Romagnoli R, Merighi S, Gessi S, Baraldi PG, Borea PA, Varani K. TRR469, a potent A1 adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice. Neuropharmacology, 2014; 81: 6-14.
http://www.ncbi.nlm.nih.gov/pubmed/24486382
[2] Gessi S, Merighi S, Stefanelli A, Fazzi D, Varani K, Borea PA. A1 and A3 adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes. Pharmacol Res, 2013; 76: 157-170.
http://www.ncbi.nlm.nih.gov/pubmed/23969284
[3] Vincenzi F, Corciulo C, Targa M, Merighi S, Gessi S, Casetta I, Gentile M, Granieri E, Borea PA, Varani K. Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulated. Eur J Immunol, 2013; 43: 2206-2216.
http://www.ncbi.nlm.nih.gov/pubmed/23661562
[4] Varani K, Vincenzi F, Targa M, Paradiso B, Parrilli A, Fini M, Lanza G, Borea PA. The stimulation of A3 adenosine receptors reduces bone-residing breast cancer in a rat preclinical model. Eur J Cancer, 2013; 49: 482-491.
http://www.ncbi.nlm.nih.gov/pubmed/22770890
[5] Gessi S, Merighi S, Stefanelli A, Mirandola P, Bonfatti A, Fini S, Sensi A, Marci R, Varani K, Borea PA, Vesce F. Downregulation of A1 and A2B adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi. Biochim Biophys Acta, 2012; 1822: 1660-1670.
Affiliation: University of Camerino
Principal Investigator: Loredana Cappellacci
[1] Petrelli R, Scortichini M, Belardo C, Boccella S, Luongo L, Capone F, Kachler S, Vita P, Del Bello F, Maione S, Lavecchia A, Klotz K-N, Cappellacci L. Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists. J Med Chem, 2018; 61: 305-318.
https://www.ncbi.nlm.nih.gov/pubmed/29257884
[2] Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, Del Bello F, Salvemini D, Novellino E, Luongo L, Maione S, Jacobson K, Lavecchia A, Klotz K-N, Cappellacci L. Exploring the role of N6-substituents in potent dual acting 5’-C-ethyl-tetrazolyl-adenosine derivatives: synthesis, binding, functional assays and antinociceptive effects in mice. J Med Chem, 2017; 60: 4327-4341.
https://www.ncbi.nlm.nih.gov/pubmed/28447789
[3] Petrelli R, Grifantini M, Cappellacci L. Development of C-Methyl Branched Purine Ribonucleoside Analogs: Chemistry, Biological Activity and Therapeutic Potential. Curr Med Chem, 2016; 23: 3118-3135.
https://www.ncbi.nlm.nih.gov/pubmed/27356543
[4] Petrelli R, Torquati I, Kachler S, Luongo L, Maione S, Franchetti P, Grifantini M, Novellino E, Lavecchia A, Klotz K-N, Cappellacci L. 5′‑C‑Ethyl-tetrazolyl‑N6‑Substituted Adenosine and 2‑Chloroadenosine Derivatives as Highly Potent Dual Acting A1 Adenosine Receptor Agonists and A3 Adenosine Receptor Antagonists. J Med Chem, 2015; 58: 2560-2566.
https://www.ncbi.nlm.nih.gov/pubmed/25699637
[5] Luongo L, Petrelli R, Gatta L, Giordano C, Giuda F, Vita P, Franchetti P, Grifantini M, De Novellis V, Cappellacci L, Maione S. 5’-Chloro-5’-deoxy-(±)-ENBA, a Potent and Selective Adenosine A1 Receptor Agonist, Alleviates Neuropathic Pain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions. Molecules, 2012; 17: 13712-13726.
Affiliation: University of Naples Federico II
Principal Investigator: Carla Cicala
[1] Caiazzo E, Cerqua I, Riemma MA, Turiello R, Ialenti A, Schrader J, Fiume G, Caiazza C, Roviezzo F, Morello S, Cicala C. Exacerbation of Allergic Airway Inflammation in Mice Lacking ECTO-5'-Nucleotidase (CD73). Front Pharmacol, 2020; 11: 589343.
https://pubmed.ncbi.nlm.nih.gov/33328996/
[2] Caiazzo E, Bilancia R, Rossi A, Ialenti A, Cicala C. Ectonucleoside Triphosphate Diphosphohydrolase-1/CD39 Affects the Response to ADP of Female Rat Platelets. Front Pharmacol, 2020; 10: 1689.
https://pubmed.ncbi.nlm.nih.gov/32082171/
[3] Caiazzo E, Morello S, Carnuccio R, Ialenti A, Cicala C. The Ecto-5'-Nucleotidase/CD73 Inhibitor, α,β-Methylene Adenosine 5'-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat. Front Pharmacol, 2019; 10: 775.
https://pubmed.ncbi.nlm.nih.gov/31354490/
[4] Ialenti A, Caiazzo E, Morello S, Carnuccio R, Cicala C. Adenosine A(2A) Receptor Agonist, 2-p-(2-Carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride hydrate (CGS21680), Inhibits Inflammation and Increases Fibroblast Growth Factor 2 (FGF-2) Tissue Expression in Carrageenan Induced Rat Paw Edema. J Pharmacol Exp Ther, 2018; 364: 221-228.
https://www.ncbi.nlm.nih.gov/pubmed/29212832
[5] Caiazzo E, Maione F, Morello S, Lapucci A, Paccosi S, Steckel B, Lavecchia A, Parenti A, Iuvone T, Schrader J, Ialenti A, Cicala C. Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem Pharmacol, 2016; 112: 72-81.
Affiliation: University of Chieti
Principal Investigator: Renata Ciccarelli, Patrizia Di Iorio
[1] Giuliani P, Zuccarini M, Buccella S, Rossini M, D'Alimonte I, Ciccarelli R, Marzo M, Marzo A, Di Iorio P, Caciagli F. Development of a new HPLC method using fluorescence detection without derivatization for determining purine nucleoside phosphorylase activity in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 2016; 1009-1010: 114-121.
http://www.ncbi.nlm.nih.gov/pubmed/26720700
[2] D'Alimonte I, Nargi E, Zuccarini M, Lanuti P, Di Iorio P, Giuliani P, Ricci-Vitiani L, Pallini R, Caciagli F, Ciccarelli R. Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells. Purinergic Signal, 2015; 11: 331-346.
http://www.ncbi.nlm.nih.gov/pubmed/25976165
[3] Giuliani P, Ballerini P, Buccella S, Ciccarelli R, Rathbone MP, Romano S, D'Alimonte I, Caciagli F, Di Iorio P, Pokorski M. Guanosine protects glial cells against 6-hydroxydopamine toxicity. Adv Exp Med Biol, 2015; 837: 23-33.
http://www.ncbi.nlm.nih.gov/pubmed/25310956
[4] D'Alimonte I, Nargi E, Lannutti A, Marchisio M, Pierdomenico L, Costanzo G, Di Iorio P, Ballerini P, Giuliani P, Caciagli F, Ciccarelli R. Adenosine A1 receptor stimulation enhances osteogenic differentiation of human dental pulp-derived mesenchymal stem cells via WNT signaling. Stem Cell Res, 2013; 11: 611-624.
http://www.ncbi.nlm.nih.gov/pubmed/23651584
[5] Connell BJ, Di Iorio P, Sayeed I, Ballerini P, Saleh MC, Giuliani P, Saleh TM, Rathbone MP, Su C, Jiang S. Guanosine protects against reperfusion injury in rat brains after ischemic stroke. J Neurosci Res, 2013; 91: 262-72.
Affiliation: University of Firenze
Principal Investigator: Felicita Pedata
[1] Pedata F, Dettori I, Coppi E, Melani A, Fusco I, Corradetti R and Pugliese AM. Purinergic signalling in brain ischemia. Neuropharmacology, 2016; 104: 105-130.
http://www.ncbi.nlm.nih.gov/pubmed/26581499
[2] Maraula G, Traini C, Mello T, Coppi E, Galli A, Pedata F and Pugliese AM. Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: Role of A2A adenosine receptors. Neuropharmacology, 2013; 67: 511-520.
http://www.ncbi.nlm.nih.gov/pubmed/23261865
[3] Coppi E, Maraula G, Marta Fumagalli M, Paola Failli P, Cellai L, Bonfanti E, Abbracchio MP, Pedata F and Pugliese AM. UDP-glucose enhances outward K(+) currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors. Glia, 2013; 61: 1155-1171.
http://www.ncbi.nlm.nih.gov/pubmed/23640798
[4] Melani A, Corti F, Stephan H, Müller CE, Donati C, Bruni P, Vannucchi MG and Pedata F. Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum. Exp Neurol, 2012; 233: 193-204.
http://www.ncbi.nlm.nih.gov/pubmed/22001157
[5] Paterniti I, Melani A, Cipriani S, Corti F, Mello T, Mazzon E, Esposito E, Bramanti P, Cuzzocrea S and Pedata F. Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects. J Neuroinflammation, 2011; 8: 31.
Affiliation: Istituto Superiore di Sanità
Principal Investigator: Patrizia Popoli
[1] Chiodi V, Ferrante A, Ferraro L, Potenza RL, Armida M, Beggiato S, Pèzzola A, Bader M, Fuxe K, Popoli P, Domenici MR. Striatal adenosine-cannabinoid receptor interactions in rats over-expressing adenosine A2A receptors. J Neurochem, 2016; 136: 907-917.
https://www.ncbi.nlm.nih.gov/pubmed/26526685
[2] Ferrante A, De Nuccio C, Pepponi R, Visentin S, Martire A, Bernardo A, Minghetti L, Popoli P. Stimulation of adenosine A2A receptors reduces intracellular cholesterol accumulation and rescues mitochondrial abnormalities in human neural cell models of Niemann-Pick C1. Neuropharmacology, 2016; 103: 105-162.
https://www.ncbi.nlm.nih.gov/pubmed/26631535
[3] Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AM, Popoli P, Domenici MR. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology, 2014; 39: 569-578.
http://www.ncbi.nlm.nih.gov/pubmed/23989619
[4] Martire A, Pepponi R, Domenici MR, Ferrante A, Chiodi V, Popoli P. BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2A receptor is involved. J Neurochem, 2013; 125: 225-235.
http://www.ncbi.nlm.nih.gov/pubmed/23363456
[5] Visentin S, De Nuccio C, Bernardo A, Pepponi R, Ferrante A, Minghetti L, Popoli P. The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients. J Neurosci, 2013; 33: 15388-15393.
Affiliation: Consiglio Nazionale delle Ricerche - CNR
Principal Investigator: Claudia Verderio
[1] Prada I, Gabrielli M, Turola E, Iorio A, D'Arrigo G, Parolisi R, De Luca M, Pacifici M, Bastoni M, Lombardi M, Legname G, Cojoc D, Buffo A, Furlan R, Peruzzi F, Verderio C. Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations. Acta Neuropathol, 2018; Jan 4. doi: 10.1007/s00401-017-1803-x.
https://www.ncbi.nlm.nih.gov/pubmed/29302779
[2] Drago F, Lombardi M, Prada I, Gabrielli M, Joshi P, Cojoc D, Franck J, Fournier I, Vizioli J, Verderio C. ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes. Front Pharmacol, 2017; 8: 910.
http://www.ncbi.nlm.nih.gov/pubmed/22661954
[3] Filipello F, Pozzi D, Proietti M, Romagnani A, Mazzitelli S, Matteoli M, Verderio C, Grassi F. Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling. Oncotarget, 2016; 7: 5143-5156.
http://www.ncbi.nlm.nih.gov/pubmed/22246184
[4] Joshi P, Turola E, Ruiz A, Bergami A, Libera DD, Benussi L, Giussani P, Magnani G, Comi G, Legname G, Ghidoni R, Furlan R, Matteoli M, Verderio C. Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles. Cell Death Differ, 2014; 21: 582-593.
http://www.ncbi.nlm.nih.gov/pubmed/24336048
[5] Verderio C, Muzio L, Turola E, Bergami A, Novellino L, Ruffini F, Riganti L, Corradini I, Francolini M, Garzetti L, Maiorino C, Servida F, Vercelli A, Rocca M, Dalla Libera D, Martinelli V, Comi G, Martino G, Matteoli M, Furlan R. Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann Neurol, 2012; 72: 610-624.
Affiliation: Consiglio Nazionale delle Ricerche - CNR
Principal Investigator: Cinzia Volonté
[1] Fabbrizio P, Amadio S, Apolloni S, Volonté C. P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia. Front Cell Neurosci, 2017; 11: 249.
https://www.ncbi.nlm.nih.gov/pubmed/28871219
[2] Amadio S, Parisi C, Piras E, Fabbrizio P, Apolloni S, Montilli C, Luchetti S, Ruggieri S, Gasperini C, Laghi-Pasini F, Battistini L, Volonté C. Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis. Front Immunol, 2017; 8: 1529.
https://www.ncbi.nlm.nih.gov/pubmed/29187851
[3] Apolloni S, Fabbrizio P, Amadio S, Napoli G, Verdile V, Morello G, Iemmolo R, Aronica E, Cavallaro S, Volonté C. Histamine Regulates the Inflammatory Profile of SOD1-G93A Microglia and the Histaminergic System Is Dysregulated in Amyotrophic Lateral Sclerosis. Front Immunol, 2017; 8: 1689.
https://www.ncbi.nlm.nih.gov/pubmed/29250069
[4] Parisi C, Napoli G, Amadio S, Spalloni A, Apolloni S, Longone P, Volonté C. MicroRNA-125b regulates microglia activation and motor neuron death in ALS. Cell Death Differ, 2016; 23: 531-541.
http://www.ncbi.nlm.nih.gov/pubmed/26794445
[5] Volonté C, Apolloni S, Parisi C, Amadio S. Purinergic contribution to amyotrophic lateral sclerosis. Neuropharmacol, 2016; 104: 180-193.
Affiliation: University of Camerino
Principal Investigator: Rosaria Volpini
[1] Dal Ben D, Marchenkova A, Thomas A, Lambertucci C, Spinaci A, Marucci G, Nistri A, Volpini R. 2′,3′-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents. Purinergic Signal, 2017; 13: 61-74.
https://www.ncbi.nlm.nih.gov/pubmed/27757785
[2] Thomas A, Buccioni M, Dal Ben D, Lambertucci C, Marucci G, Santinelli C, Spinaci A, Kachler S, Klotz K-N, Volpini R. The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor. ChemMedChem, 2016; 19: 1829-1839.
http://www.ncbi.nlm.nih.gov/pubmed/27037522
[3] Marucci G, Dal Ben D, Lambertucci C, Santinelli C, Spinaci A, Thomas A, Volpini R, Buccioni M. The G Protein-Coupled Receptor GPR17: Overview and Update. ChemMedChem, 2016; 11: 2567-2574.
https://www.ncbi.nlm.nih.gov/pubmed/27863043
[4] Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Thomas A, Volpini R. Purinergic P2X receptors: Structural models and analysis of ligand-target interaction. Eur J Med Chem, 2015; 89: 561-580.
http://www.ncbi.nlm.nih.gov/pubmed/25462266
[5] Volpini R, Buccioni M, Dal Ben D, Lambertucci C, Lammi C, Marucci G, Ramadori AT, Klotz KN, Cristalli G. Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor. J Med Chem, 2009: 52: 7897-7900.
http://www.ncbi.nlm.nih.gov/pubmed/19839592
